Correlation between adiponectin, leptin, insulin growth factor-1 and bone mineral density in pre and postmenopausal women.

UNLABELLED Body weight positively correlates with bone mass, gravity being a stimulating bone stress. Adipose tissues could influence bone metabolism especially in postmenopause. Also, muscle mass positively correlates with bone mass and is dependent on physical activity, but also on some hormones with direct effect on bone, such as insulin growth factor-1 (IGF-1). AIM Our study investigated the relative influence on lumbar bone mass of pre and postmenopausal women of body weight, leptin, adiponectin and IGF-1. MATERIAL AND METHODS Cross-sectional study including six groups of 8 to 15 pre and postmenopausal healthy volunteers with different weight: body mass index (BMI): normal and underweight (BMI<25 kg/m2), overweigh: (BMI 25-30 kg/m2), and obese (BMI>30 kg/m2). Lumbar bone mineral density (BMD) and body composition (BC) were evaluated by dual X ray absorptiometry (DXA, Hologic), while serum leptin, adiponectin and IGF-1 were measured by ELISA. RESULTS Body weight, fat and lean mass positively correlated with BMD, irrespective of age (p<0.05, ANOVA). Leptin was an independent predictor for bone mass only in postmenopausal women (p<0.05). Adiponectin negatively correlated (R2=0.1975) and IGF-1 positively correlated with body mass (p<0.05). CONCLUSIONS Increased body weight prevents bone loss after menopause. Leptin and IGF-1 have adjacent positive roles in preserving bone mass during postmenopause.